Opera Browser Disables Keystrokes in other Apps [O-63 / W-1809]

Recently I’ve been experiencing intermittent issues in trying to use certain keystrokes in a few of my more common Windows-based applications. The two primary shortcuts I found that I cannot use are Ctrl-Shift-Home and Ctrl-Shift-End. These two shortcuts should highlight from the current cursor position to either the top or bottom of the available selection